Northwestern College is situated on a 100-acre campus in Orange City, Iowa, a community of about 6,000 people located in the northwest corner of the state. Among its major buildings are both historic architecture and award-winning facilities, including:

• The Vogel Welcome Center, opened in 2021
• The Bultman Center for Health, Physical Education and Intercollegiate Athletics, renovated in 2021
• The DeWitt Family Science Center, opened in 2018
• The Juffer Athletic Fieldhouse, opened in 2015
• The Ramaker Center, renovated in 2014
• The DeWitt Learning Commons, opened in 2013
• The DeWitt Physical Fitness Center, renovated in 2011 and 2013
• The Rowenhorst Student Center, renovated in 2007
• The DeWitt Theatre Arts Center, opened in 2004
• The Korver Visual Arts Center, opened in 2003
• Christ Chapel and the DeWitt Music Hall, opened in 1987
• Zwemer Hall, built in 1894 and restored in 1997 (listed in the National Register of Historic Places)